In 2020, Inexios developed Inexiotech for gradient, making the intensification technology available for peptide and proteins.
Peptide synthesis can lead to sequence deletions which make the separation difficult as there are impurities very similar to the product of interest. Generally, the major cost driver is the purification yield as the crude to be purified is already high value. Inexiotech provides very substantial gains by increasing the yield / product recovery by a factor of 2 to 4.
On proteins, high dilutions and particular solvents can be used to prevent folding, which is detrimental to the purification step downstream. The implementation of Inexiotech allows to recover the performance by reducing the consumption of eluant.